منابع مشابه
Properties of Antibodies Cytophilic for Macrophages* by Arthur Berken,$ M.d., and Baruj Benacerraf,§ M.d
The production of an antibody cytophilic for spleen cells in rabbits immunized with human serum albumin was described by Boyden and Sorkin (1, 2, 3) several years ago. These investigators detected the presence of cytophilic antibody by the capacity of the antisera to confer upon normal cells the capability of specifically adsorbing radio-iodinated antigen. Among the deficiencies in such a syste...
متن کاملSurface Immunog lobu l in Receptors BY KENNETH L . ROCK , BARUJ BENACERRAF , AND ABUL
Cells of the monocyte/macrophage lineage, dendritic cells, and a variety of other cell types that express class II histocompatibility (Ia) molecules on their surfaces are capable of presenting foreign protein antigens to and stimulating Iarestricted inducer (helper) T lymphocytes (1-3). After the demonstration that B cells also bear Ia antigens (4) and that at least some interactions between an...
متن کاملQuantitative Variations in L Chain Types in Guinea Pig Antihapten Antibodies* by Victor Nussenzweig, M.d., and Baruj Benacerraf, M.d
I t is well known that mammalian immunoglobulins x consist of two types of polypeptide chains, H and L (1, 2). In human ]mmunoglobulins, L chains were found to be of two distinct types (a and )~) which differ widely in their amino acid composition and in the peptides which can be detected by fingerprint analysis (3). Two types of molecules (K or I,) bearing either Kor ),-types of L chains, in a...
متن کاملPREFERENTIAL DEPRESSION OF TIIE HIGH AFFINITY ANTIBODY RESPONSE BY JOSEPH M. DAVIE, WILLIAM E. PAUL, DAVID H. KATZ, ANn BARUJ BENACERRAF
The treatment of guinea pigs with 2,4-dinitrophenyl (DNP) t derivatives of the copolymer of D-glutamic acid and D-lysine (D-GL) induces a state of specific immunologic tolerance in the recipient (1). The type of tolerance induced is unusual in that it is DNP specific. That is, challenge of such guinea pigs with a DNP conjugate of ovalbumin (DNP-OVA) elicits anti-DNP responses markedly smaller t...
متن کاملIn Vitro Studies on T H E Interaction between Mouse Peritoneal Macrophages and Strains of Salmonella and Escherichia Coli* by Charles Jenkin,$ Ph.d., and Baruj Benacerraf, M.d
Studies on Salmonella infections in mice showed that the injected bacteria are cleared rapidly from the circulation, and may be found mainly in the liver, and spleen, the principal organs of the reticuloendothelial system (RES) (1). Investigations of the fate of the bacteria in these organs revealed that whereas the population of a virulent strain of Salmonella increases, that of an avirulent s...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2011
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.2110